Human Type III Collagen

Type III collagen consists of three alpha 1(III) chains in a triple helix structure and is distributedin connective tissues such as skin, liver, lung, and intestines, along with type I collagen to makeup the interstitial matrix structure. Therefore, type III collagen is considered a minor companioncollagen with type I collagen, which is the dominant collagen in the tissues (1). Type III collagenis involved in scaffolding and scar tissue formation and its contents in normal tissues arenormally very low. However, under wound healing conditions, the ratio of type I to type IIIcollagen reaches 1:2, resulting in a loss of tensile strength (2). Thus, this immunization gradetype III collagen can be a useful tool to study the mechanism of wound healing and connectivetissue related diseases